Dr. Linda Schuler, Professor
Joined ERP Program: 1986
Department: Comparative Biosciences, School of Veterinary Medicine
Address: 4354B Veterinary Medicine Bldg, 2015 Linden Dr., Madison, WI 53706
Telephone: (608) 263-9825 FAX: (608) 263-3926
Email: schulerl@svm.vetmed.wisc.edu
Background:
| Institution | Degree | Year | Area of Study |
| University of Wisconsin-Madison | B.S. | 1974 | Zoology |
| University of Pennsylvania, Philadelphia | Ph.D. | 1980 | Physiology |
| University of Pennsylvania School of Veterinary Medicine | V.D.M. | 1981 | Veterinary Med. |
Professional Experience:
| 1981-1983 | Postdoctoral Fellow, Department of Biochemistry, University of Wisconsin-Madison |
| 1983-1989 | Assistant Professor, School of Veterinary Medicine, University of Wisconsin-Madison |
| 1989-1997 | Associate Professor, Department of Comparative Biosciences, School of Veterinary Medicine, University of WI-Madison |
| 1997- Pres | Professor, Department of Comparative Biosciences, School of Veterinary Medicine, University of WI-Madison |
| 1999-Pres | Adjunct Professor, Department of Medicine, Medical School, University of WI-Madison |
| 1995-Pres | Member, University of Wisconsin Comprehensive Cancer Center |
Honors and Awards:
- Fellow, Veterinary Medical Scientist Training Program, 1976-1981
- Phi Zeta Honor Society, 1979; Phi Zeta Research Award, 1981
- V.M.D. magna cum laude, 1981
- Shaw Scholarship, 1986
- Smith Kline Beecham Award for Research Excellence, 1993
- Renk Distinguished Professor, 1999
- USDA Growth and Development review panel, 1989, 1990
- USDA Molecular Genetics review panel, 1992
- ARMY Breast Cancer review panel, 1994, 1995, 1996, 1997
- Committee of Visitors, Physiological Processes, NSF, 1991
- ad hoc reviewer for NSF, BARD, March of Dimes, USDA Competitive Grants Program, Small Business Innovative Research., NIH Biochemical Endocrinology (BCE), 1999-present
- NIH Human Embryonic Development (HED-1); regular member 1997-present
Research Statement:
The Schuler laboratory is interested in the interactions of prolactin and related hormones with other growth factors and hormones at fetal and maternal targets during pregnancy. They have extended studies on the actions of prolactin in mammary alveolar development during pregnancy to its role in the development and progression of mammary cancer. Using a variety of in vitro models, they examine control of receptor expression including receptor internalization and linkage to signal transduction, cell specific target genes, and signaling pathways employed. They have developed transgenic mouse models using a non-hormonally responsive, mammary specific promoter in order to examine interactions on preneoplastic processes in vivo.
Former ERP Graduate Students:
- Juu-Chin Lu, PhD 5/02
Current Grant Funding
| Funding Period | Project |
7/1/02-6/30/07 |
L.Schuler (PI) NIH.R01 CA78312 |
| 6/1/03-5/31/07 | L Schuler (PI) NIH R01DK062783. Endocytosis and trafficking of PRL receptor isoforms |
| 04/01/06 to 03/31/11 | L. Schuler (PI) NIH 1 K01 RR021858-01 Interactions of PRI, Estrogen and TGFA in Mammary Cancer |