Dr. Jon Odorico, Associate Professor
Joined ERP Program: 2002
Department: Transplant Surgery, Faculty Profile
Mailing Address: H4/756 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792-7375
Telephone: (608) 263-4768 FAX: (608) 262-6280
E-Mail: jon@surgery.wisc.edu
Background:
| Institution | Degree | Year | Field of Study |
| Duke University, Durham, NC | BS | 1983 | Chemistry |
| New York University, New York, NY | MD | 1987 | Medicine |
Professional Experience:
| 1987-1992 | Resident, General Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA |
| 1990-1992 | Postdoctoral Research Fellow, Harrison Department of Surgical Research, Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA |
| 1993-1994 | Chief Resident, General Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA |
| 1994-1996 | Fellow, Transplant Surgery, University of Wisconsin Hospital & Clinics, Madison, WI |
| 1996-2005 | Assistant Professor, Department of Surgery, Division of Organ Transplantation, University of Wisconsin Hospital & Clinics, Madison, WI |
| 2001-present | Associate, WiCell Institute, Madison, WI |
| 2005 - Present | Associate Professor, Department of Surgery, Division of Organ Transplantation, University of Wisconsin Hospital & Clinics, Madison, WI |
Honors and Awards:
- Merck Index Award, 1983
- Phi Lambda Upsilon Chemical Honor Society, 1983
- Magna Cum Laude, Duke University, 1983
- National Research Service Award, National Institutes of Health, 1990-1992
- Jonathon E. Rhoads Research Award, Harrison Department of Surgical Research, University of Pennsylvania, School of Medicine, 1992-1993
- Finalist, Sandoz Fellowship Award, 1994
- Best Abstract Award, OrthoBiotech Transplant Fellows Workshop, 1994
- American Society of Transplant Surgeons, Fujisawa Faculty Development Award, 1996
Research Statement:
Our laboratory is interested in using embryonic stem (ES) cells to study pancreatic islet development. Despite advances in our understanding of islet ontogeny, there are still significant gaps in our knowledge. Specifically, we do not yet understand precisely how insulin secreting beta cells and other endocrine cell types within mammalian pancreatic Islets of Langerhans are specified from embryonic foregut endoderm, or what complement of transcription factors direct this fate choice. Furthermore, what is the exact phenotype of islet progenitor cells, and what are the critical epithelial - mesenchymal interactions that guide this developmental process, are important questions that have not been answered. We have recently described the derivation of islet progenitor cells and mature islet cell types expressing insulin, glucagon, somatostatin, and pancreatic polypeptide from murine ES cells induced to differentiate in culture. In this in vitro differentiation system many aspects of normal islet development are reproduced, thus offering a simple, controllable culture model in which to study islet ontogeny.
Current Grant Funding:
| Funding Period | Project |
| 02/01/00 to / / | J. Odorico (PI) Novartis RAD1A06 A Multicenter, Open Label, Exploratory Study To Assess the Safety and Tolerability Of Simulect, Neoral, RAD001 and Steroids for the Prevention of Acute Rejection in Diabetic Patients Undergoing Simultaneous Pancreas-Kindey. |
| 07/01/06 to 06/30/08 | J. Odorico (PI) American Society of Transplant Surgeons The Role of BMP4 in Endoderm and Pancreas Specification from Human Embryonic Stem Cells |
| 10/1/01-9/30/06 | Dr. Odorico is the PI on the project at the University of Wisconsin that was submitted as part of this program project application (University of Minnesota, C. Verfaillie, PI).U19 DK61244 NIH, NIDDK, Beta Cell Consortium Islet Stem Cells from Murine ES Cells |