Dr. Colin Jefcoate, Professor
Joined ERP Program:

Department: Molecular and Cellular Pharmacology
Address: 2640 Medical Sciences Center, 1300 University Ave, Madison, WI 53706
Telephone: (608) 263-3975
Email: jefcoate@wisc.edu

Background:

Institution Degree Year Area of Study
Oxford University , Oxford , England B.A./B.S. 1963 Chemistry
Oxford University , Oxford , England Ph.D. 1966 Chemistry

Professional Experience:

1966 D. Phil (Chemistry) under R.O.C. Norman, Oxford (including one year at York University )
1966-1967 NATO Fellow with P. Hemmerich, Basel University , Switzerland
1967-1969 NIH and NATO Fellow with J.L. Gaylor, Cornell University , Ithaca
1972 Visiting Scientist with W.H. Orme-Johnson, Biochemistry, University of Wisconsin-Madison (UW-Madison)
1972-1973 Research Associate with W.H. Orme-Johnson, Biochemistry, UW-Madison
1973-1978 Assistant Professor, Pharmacology, UW-Madison
1978-1982 Associate Professor, Pharmacology, UW-Madison
1982-present Professor, Pharmacology, UW-Madison
1983-1998 Director, Environmental Toxicology Center , UW-Madison
1998-present Director, NIEHS Center for Developmental and Molecular Toxicology, UW-Madison

Honors and Awards:

  • 1964 2nd Class Honors in Natural Sciences (Chemistry)
  • 1969-1972 MRC Fellow with G.S. Boyd, Edinburgh University , Edinburgh, Scotland
  • 1998-2003 WARF Mid-Career Faculty Researcher Award

Research Statement:

Our research addresses signaling mechanisms involving P450 cytochromes. These regulate activity at nuclear receptors regulated by three types of activator.

  • cholesterol/steroid hormones
  • fatty acids and metabolites
  • Ah receptor/PCB's and polycyclic aromatic hydrocarbons

Current Graduate Students:

Jinwoo Lee jwlee7@wisc.edu Ph.D.

Current Grant Funding:

Funding Period Project 
12/15/05 to 01/14/07 C. Jefcoate (PI) Dept. of Defense - Army W81XWH-06-1-0205. Regulation of Tumor Cell Growth by the Mesenchymal Environment of the Bone Marrow is Enhanced by a High Fat Diet
09/01/06 to 08/31/07 C. Jefcoate (PI) NIH Mechanisms for Acquired Changes in Prostate Growth Regulation: Impact on Bone Stromal Cell Differentiation on Prostate Tumor Cell Growth

 

Publications from Dr. Jefcoate's Laboratory  Search PubMed