Dr. Thaddeus Golos, Professor
Joined ERP Program: 1995

Department: Comparative Biosciences ; Wisconsin National Primate Center
Mailing Address: 115 Primate Center, 1220 Capitol Court, Madison, WI 53715
Telephone: (608) 263-3567  FAX: (608) 263-3524
E-mail: golos@primate.wisc.edu

Background:

Institution Degree Year Area of Study
Marquette University B.S. 1978 Biology
University of Illinois, Urbana M.S.
Ph.D.		 1982- 1984 Physiology
University of Pennsylvania Postdoc 1984-1987 OB/GYN

Professional Experience:

1978  

Laboratory Assistant, Medical College of Wisconsin, Milwaukee,  Wisconsin

1978-1984

Teaching/Research Assistant, University of Illinois, Urbana, Illinois

1984-1987

 Postdoctoral Fellow, University of Pennsylvania, Philadelphia,  Pennsylvania

1987-1994

Assistant Scientist, Wisconsin Regional Primate Research Center, Univ.  of Wisconsin, Madison, WI

1995-1999

Assistant Professor, Dept. of Obstetrics and Gynecology, University of  Wisconsin Medical School, Associate Scientist, Wisconsin Regional Primate Research Center, Univ. of Wisconsin, Madison, WI

1997-present

Chair, Reproduction and Development Research Group, WRPRC.

1999-2003  

Associate Professor, Dept. of Obstetrics and Gynecology, University of Wisconsin Medical School

2003 - present

Professor, Dept. of Obstetrics and Gynecology, University of Wisconsin Medical School

 

Honors and Awards:

  • NIH Predoctoral Fellowships, Reproductive Biology (1980-81) and Cellular and Molecular Biology (1982-84) Training Programs, University of Illinois;
  • USPHS Individual Postdoctoral NRSA, University of Pennsylvania, 1985-87;
  • Human Embryology and Development and Reproductive Biology Study Sections;
    Regular member Biochemical Endocrinology, Study Section (1997-2001);
  • Editorial Board, Journal of Molecular Endocrinology, 1996-2000; Placenta, 2003-2005.

Research Statement:

My laboratory examines questions of placental biology relevant to human health and disease. We use nonhuman primate models, as well as human clinical materials in our studies.  Under this broad focus, research areas include the transcriptional control of and embryonic stem cells of the specification of the trophoblast lineage (of particular interest are basic helix-loop-helix and homeobox transcription factors), trphoblast differentiation and placental morphogensis; maternal-fetal immune tolerance (nonpolymorphic MHC class I molecules on a subset of placental cells and their interactions with the maternal immune system), placental development and function in the clinical setting of maternal diabetes, particularly the influences of glucose and oxygen on placental vascular development, and gene therapy and gene transfer at the primate maternal-fetal interface to develop experimental and therapeutic models of utero-placental function and dysfunction.

Current Grant Funding:

Funding Period Project
04/01/06 to 03/31/10

T. Golos (PI) NIH 1 R01 RR021876-01
A Primate ES Cell Model For Embryo Implantation

06/01/08 to 05/31/10 T. Golos (PI) R21AI076734
Primate Endometrial Responses to Placental MHC Class I Molecules
04/01/07 to 03/31/09 T. Golos (PI) R21HD053925
A Primate In Vitro Implantation Model

Current ERP Graduate Students:

Maria Giakoumopoulos giakoumopoul@wisc.edu Ph.D.
Ann Rozner annbaker@wisc.edu Ph.D.

Former ERP Student Trainees:

  • Yi Qin, Masters, 12/99
    Thesis Title: "Factors regulating the transcriptional activity of the Rhesus monkey growth hormone variant (mGH-V) promoter"

  • Michael Wolfgang, Ph.D. 5/02
    Dissertation Title: "Cellular and Molecular approaches for the study of maternal-fetal immune tolerance in nonhuman primates"

  • Dinesh Rao, Masters, 12/03
    Thesis Title: "The identification, cloning and sequencing of leukocyte immunoglobulin-like receptors in the rhesus monkey"

  • Leah Pollastrini, M.S. 8/05
    Thesis Title: "Environment dependent effects of placental fibroblast co-culture on human embryonic stem cell differentiation"

  • Behzad Gerami-Naini, Ph.D. 12/06
    Dissertation Title: "Human embryonic stem cells as a model for trophoblast differentiation"

  • Tien-Cheng (Arthur) Chang, PhD 8/07
    Dissertation Title: "A three-dimensional in vitro model for studying primate embryo implantation"

  • Jessica Drenzek, PhD 8/08
    Disstertation Title: "Mechanisms of maternal-fetal immune tolerance in nonhuman primates"

Publications from Dr. Golos' Lab Search Pub Med